|
T6085 |
PF-543
|
Sphingosine Kinase 1 Inhibitor II,PF 543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
|
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM. |
|
T8461 |
SKI V
|
|
Apoptosis
,
PI3K
,
S1P Receptor
|
|
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induces apoptosis and has antitumor activity |
|
T16128 |
MP-A08
|
|
S1P Receptor
|
|
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively). |
|
T4658 |
MHP
|
Methyl caprooyl tyrosinate |
S1P Receptor
|
|
MHP (Methyl caprooyl tyrosinate) is an activator of sphingosine kinase (SPHK1), and significantly stimulates CAMP mRNA and protein production in KC. |
|
T6673 |
SKI II
|
SphK-I2 |
Apoptosis
,
Wnt/beta-catenin
,
S1P Receptor
|
|
SKI II (SphK-I2) is a highly selective and non-ATP-competitive S1P receptor inhibitor (IC50: 0.5 μM) while exhibiting no inhibitory action on other kinases including PKCα, PI3K, and ERK2. |
|
T8840 |
PF-543 hydrochloride
|
PF-543 |
Apoptosis
,
S1P Receptor
,
Autophagy
,
LPL Receptor
|
|
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform. |
|
T6750 |
Opaganib
|
ABC294640 |
S1P Receptor
|
|
Opaganib (ABC294640) is an orally active and specific sphingosine kinase-2 (SphK2) inhibitor (IC50: 60 μM). |
|
TQ0138 |
K145 hydrochloride
|
|
Apoptosis
,
S1P Receptor
|
|
|
|
T9014 |
SKI-178
|
|
Apoptosis
,
S1P Receptor
|
|
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ... |
|
TQ0064 |
Peretinoin
|
NIK333 |
HCV Protease
,
Retinoid Receptor
,
S1P Receptor
,
Autophagy
|
|
Peretinoin (NIK333) is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as RXR and RAR. |
|
T12148 |
N-Desmethyltamoxifen hydrochloride
|
|
Estrogen Receptor/ERR
,
Endogenous Metabolite
,
PKC
|
|
N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans. |
|
T12436 |
PF-543 Citrate
|
Sphingosine Kinase 1 Inhibitor II Citrate |
S1P Receptor
|
|
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ). |
|
T3148 |
MK-571 sodium
|
L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid |
Leukotriene Receptor
,
LTR
|
|
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... |
|
T9992 |
SphK1&2-IN-1
|
|
S1P Receptor
|
|
SphK1&2-IN-1 is a sphingosine kinase inhibitor with anti-inflammatory, antitumor and hemostatic effects. |
|
T63047 |
SLP9101555
|
|
S1P Receptor
,
LPL Receptor
|
|
SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extrace... |
|
T27710 |
K6PC-5
|
K6PC5,K6PC 5 |
S1P Receptor
|
|
K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated ... |
|
T23045 |
N,N-Dimethylsphingosine
|
|
Others
|
|
sphingosine kinase (SphK) inhibitor |
|
T22917 |
L-threo-Sphingosine C-18
|
|
Others
|
|
L-threo-Sphingosine C-18 is a protein kinase C inhibitor. |
|
T24803 |
SKI 5C
|
SKI5C,SKI-5C |
|
|
SKI 5C is a selective inhibitor of Sphingosine Kinase 1. |
|
T70816 |
(R)-FTY720-OMe
|
|
|
|
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity. |
|
T83883 |
Biotin Sphingosine
|
Biotinyl Sphingosine |
|
|
Biotin sphingosine, a biotinylated derivative of sphingosine (d18:1), serves as a probe in assays for detecting the phosphorylation activity of sphingosine kinase 1 (SPHK1) and SPHK2 in cell lysates. |
|
T24044 |
Erythro-sphingosine, (+)-
|
L-Erythro-c18-sphingosine,L-Erythro-sphingosine |
|
|
Erythro-sphingosine, (+)- is a cell-permeable and reversible inhibitor of protein kinase C (IC50: 12 µM) and enhances Src kinase activity. |
|
T12927 |
SK1-IN-1
|
|
S1P Receptor
|
|
|
|
T70613 |
SLP120701 HCl
|
|
|
|
SLP120701 is a potent and selective sphingosine kinase 2 inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Interv... |
|
T70071 |
SLM6031434 (free base)
|
|
|
|
SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group. |
|
T71393 |
(S)-FTY-720 Vinylphosphonate
|
|
|
|
(S)-FTY-720 Vinylphosphonate inhibits sphingosine kinase 1 and promotes its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer cells, and androgen-independent prostate cancer cells. |
|
T70614 |
SLR080811 HCl
|
|
|
|
SLR080811 is a SphK inhibitor. Sphingosine-1-phosphate (S1P) is a ubiquitous, endogenous small molecule that is synthesized by two isoforms of sphingosine kinase (SphK1 and 2). Intervention of the S1P signaling pathway h... |
|
T70900 |
VT-ME6
|
|
|
|
VT-ME6 is a potent and selective sphingosine kinase 2 inhibitor. VT-ME6, contained a quaternary ammonium group as a warhead and established that a positively charged moiety is necessary for engaging key amino acid residu... |
|
T71301 |
Opaganib HCl
|
|
|
|
ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitivel... |
|
T35781 |
Sphinganine (d20:0)
|
Sphinganine (d20:0) |
|
|
Sphinganine (d20:0) is a natural isomer of dihydro-D-erythro-sphinganine (sphinganine (d18:0); that is a precursor of ceramide and sphingosine as well as a substrate for sphingosine kinases, which generate sphingosine-1... |
|
T70704 |
RB-005
|
|
|
|
RB-005 is a potent sphingosine kinase isoform 1 (SK1) inhibitor, which may serve as therapeutic agent for proliferative diseases, including hypertension. RB-005, (IC(50) = 3.6 μM), which also induced proteasomal degradat... |
|
T37548 |
Azido-FTY720
|
azido-FTY720 |
|
|
FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survi... |
|
T12148L |
N-Desmethyltamoxifen
|
|
Others
|
|
N-Desmethyltamoxifen, the principal metabolite of tamoxifen in humans, serves as an efficacious modulator of ceramide metabolism within human AML cells by inhibiting ceramide glycosylation, hydrolysis, and sphingosine ph... |
|
T63132 |
Amgen-23
|
|
|
|
Amgen-23 (compound 23) is a potent inhibitor of sphingosine kinase (SPHK), acting on SPHK1 (IC50: 20 μM) and SPHK2 (IC50: 1.6 μM). amgen-23 can be used in anticancer studies. |
|
T38946 |
C8 Dihydroceramide
|
C8 Dihydroceramide |
|
|
C8 Dihydroceramide acts as a negative control for C8 Ceramide, a cell-permeable analog of natural ceramides. C8 Ceramide, also known as N-Octanoyl-D-erythro-sphingosine, exhibits potent chemotherapeutic properties and an... |
|
T62022 |
SKI-I
|
|
|
|
SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK). SKI-I shows an IC 50 of 1.2 μM for ST-hSK. SKI-I is also a hERK2 inhibitor( IC 50 =11 μM). SKI-I induces apoptosis in tumor cell lines. |
